catharanthus roseus research articles

0000135441 00000 n NIH 0000070639 00000 n The major challenge in the pharmaceutical industry is the low production rate of these Alkaloids. (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic application of phenol red under UV@ 365 nm Aasaithambi Kalaiselvi1, Selvaraj Mohana Roopan2, Gunabalan Madhumitha2,*, Sun J, Zhao L, Shao Z, Shanks J, Peebles CAM. Clipboard, Search History, and several other advanced features are temporarily unavailable. Cell line screening of Catharanthus roseus for high yield production of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves. 0000139800 00000 n 0000112931 00000 n 0000000016 00000 n Abstract Catharanthus roseus is a tropical hardy plant grown as a pot ornamental plant for its rosy or white flowers. Periwinkle is 0000141673 00000 n The medicinal plant, Catharanthus roseus (C. roseus), accumulates a wide range of terpenoid indole alkaloids (TIAs). 0000070009 00000 n 0000002696 00000 n 0000080009 00000 n Nowadays, synthesis of metal NPs is an interesting area in nanoscience. 0000134812 00000 n This site needs JavaScript to work properly. Email: benjamin.philmus@oregonstate.edu (B. P.) and megrawm@science.oregonstate. Please enable it to take advantage of the complete set of features! Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Biotechnol Appl Biochem. (1988). The purpose of this work was to perform in silico analysis and to predict the three-dimensional structure of this protein that is not available. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. Till date, arrays of reports are available on in vitro biotechnological improvements of C. roseus. Seeds of Catharanthus roseus ‘Pacifica Polka Dot’ were purchased from PanAmerican Seed and 900 seeds were sown at Taoyuan District Agricultural Research and Extension Station (TDARES). The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. 0000087233 00000 n Research article; Open Access; Published: 21 October 2015 Anti-diabetic potential of Catharanthus roseus Linn. This book studies the production of indole alkaloids in the important medicinal plant Catharanthus roseus (L.) G. Don, commonly known as periwinkle. Histopathological s… Cells were grown for 21 days, and alkaloid accumulation was monitored during this period. Ultraviolet (UV)-B radiation acts as an elicitor to enhance the production of secondary metabolites in medicinal plants. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of -cells of pancreas in diabetic rats. 0000070481 00000 n International Journal of Crude Drug Research: Vol. 0000142143 00000 n 11, 10 DECEMBER 2016 1811 *For correspondence. 0000071189 00000 n 0000071584 00000 n It shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc. 0000004240 00000 n 111, NO. Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. Comparison of the primary structure of the encoded protein with the amino-terminal sequence of purified SSS indicated the … 20.3.6 Catharanthus roseus (Apocynaceae) C. roseus (L.) G. Don (Apocynaceae), also known as Vinca rosea and originating from Madagascar, has now spread throughout Africa as a result of human activities. Studies on animal models have shown that ethanolic extracts of the leaves and flowers of C. roseus lower blood glucose levels [55].  |  0000082703 00000 n 11, 10 DECEMBER 2016 1811 *For correspondence. startxref 0000069849 00000 n 0000140950 00000 n 33-44. 0000004198 00000 n Global warming contributes to higher temperatures and reduces rainfall for most areas worldwide. 0000073467 00000 n The C. roseus cell suspension culture A11 accumulates the terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine. Epub 2006 Jun 27. Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. 2018 Mar;115(3):673-683. doi: 10.1002/bit.26487. 0000092042 00000 n 2016 Oct;54(10):2033-43. doi: 10.3109/13880209.2016.1140213. The aim of this study was to extract and identify the major constituents, namely, the indole alkaloids, from two Apocynaceae medicinal plant family species, Catharanthus roseus and Vinca minor when using different solvents (the alcohol mixtures, the imidazolium-based ionic liquids (IL) and the novel choline- and menthol-based deep eutectic solvents (DESs)) in ultrasound-assisted processes. 0000143730 00000 n Catharanthus roseus L. (G. Don) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes. MIAs belong to a class of terpenoid indole alkaloids (TIAs). 0000135334 00000 n It is grown in gardens and parks worldwide and it has escaped from cultivation and naturalized near houses, in disturbed sites, and in natural habitats in seasonal dry and humid habitats. 0000143345 00000 n Phytochemical Composition, Antioxidant Capacity, and Enzyme Inhibitory Activity in Callus, Somaclonal Variant, and Normal Green Shoot Tissues of. Vincristine and vinblastine are indole alkaloids isolated from C. roseus that have been successfully incorporated into anticancer therapy [ 18 ]. 398 0 obj <>stream 0000072477 00000 n Also, periwinkle is still the only source of these alkaloids and their precursors, catharanthine and vindoline. 0000140109 00000 n KEY POINTS: • C. roseus yields anticancerous vincristine and vinblastine used in pharma industry. C. roseus has been widely commercialized as an ornamental plant. is a well known medicinal plant. Catharanthus roseus produces a large number of terpenoid indole alkaloids (TIAs) and is an excellent model for understanding the regulation of this class of valuable compounds. 0000004697 00000 n Catharanthus roseus is one plant recognized well in Ayurveda. The content of ajmalicine reached 2.578 and 0.895 mg/g DW in callus and in cell suspension culture, respectively. 0000089222 00000 n 0000070087 00000 n Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. This study documented the antidiabetic efficacy of the combination of C. roseus and UA in rats. Extraction yield (µg per g dry of plant material) of catharanthine and vindoline from Catharanthus roseus with the different solvents. Anticancerous; Genetic transformation; Nanotechnology; Polyploidy; Secondary metabolite; Somatic embryogenesis. 279 0 obj <> endobj The medicinal plant, Catharanthus roseus (C. roseus), accumulates a wide range of terpenoid indole alkaloids (TIAs). 0000085276 00000 n Periwinkle [Catharanthus roseus(L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years … Lee ON, Ak G, Zengin G, Cziáky Z, Jekő J, Rengasamy KRR, Park HY, Kim DH, Sivanesan I. Molecules. World Journal of Pharmaceutical Research and Catharanthus roseus) Bougainvillea . Catharanthus roseus Linn (Apocynaceae), is a traditional medicinal plant used to control diabetes, in various regions of the world. 2020 Oct 26;25(21):4945. doi: 10.3390/molecules25214945. NLM Screening and kinetic studies of catharanthine and ajmalicine accumulation and their correlation with growth biomass in Catharanthus roseus hairy roots. Cells grown in media with the pH adjusted to 7.0 produced 3.3 mg total alkaloids/g dry weight. It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat … 0000083303 00000 n 0000089169 00000 n 0000004838 00000 n  |  Abstract. The great pharmacological values, low in planta occurrence, unavailability of … Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots … Catharanthus roseus (C. roseus) and ursolic acid (UA) are ayurvedic medicines with multiple pharmacological activities including antidiabetic activity, but till date, no study is available on their combination. 0000082647 00000 n In the present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis in C. roseus using proteomic technique. 0000139741 00000 n 0000139876 00000 n 0000080634 00000 n 2019 Sep;103(18):7325-7354. doi: 10.1007/s00253-019-10035-6. Vinblastine and vincristine are two important anti-cancer drugs that are synthesized by the Terpenoid Indole Alkaloids (TIAs) pathway in periwinkle (Catharanthus roseus). 0000070166 00000 n Four distinct transformed cell lines were obtained with A. tumefaciens strains A281, BO542, and A. rhizogenes strain K599, and selected on hormone-free medium. 1, pp. 2009 Apr;52(Pt 4):313-23. doi: 10.1042/BA20080239. V, Issue 2 / May 2017 1238 INTRODUCTION Catharanthus roseus is an evergreen ever blooming herb which has its origin in central Madagascar island. %%EOF 0000142557 00000 n Catharanthus roseus is a medicinal plant with various pharmacological properties. 0000141096 00000 n Epub 2017 Nov 22. 0000091336 00000 n Epub 2019 Jul 30. Ethylene (ET) and methyl-jasmonate (MeJA) were previously reported as effective elicitors for the production of various valuable secondary metabolites of C. roseus, while a few ET or MeJA induced transcriptomic research is yet reported on this species. In this study, we investigated the in vivo antidiarrheal activity of C. roseus ethanolic leaf extract in Wistar rats. Two of its alkaloids, vincristine and vinblastine (possessing anticancerous properties), are being used copiously in pharmaceutical industries. Catharanthus roseus (L.) is a plant species known for its production of many pharmaceutically terpenoid indole alkaloids (TIAs). COVID-19 is an emerging, rapidly evolving situation. Mukherjee E, Gantait S, Kundu S, Sarkar S, Bhattacharyya S. Appl Microbiol Biotechnol. 0000080887 00000 n 0000078451 00000 n Madagascar periwinkle (Catharanthus roseus) has become a model plant for secondary metabolism studies [].The medicinal plant C. roseus possesses a large number of terpenoid indole alkaloids (TIAs) among which over 130 compounds have been isolated and identified [].The production of the most valuable dimeric alkaloids vinblastine and vincristine are extremely low in wild-type C. roseus … 26, No. 0000004276 00000 n Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. RESEARCH ARTICLE Open Access Development of efficient catharanthus roseus regeneration and transformation system using agrobacterium tumefaciens and hypocotyls as explants Quan Wang†, Shihai Xing†, Qifang Pan, Fang Yuan, Jingya Zhao, Yuesheng Tian, Yu Chen, Guofeng Wang and Kexuan Tang* Endangered in the wild, it is a fast-growing plant that is easy to cultivate. 0000074041 00000 n Biotechnological interventions on the genus Rauvolfia: recent trends and imminent prospects. It is also commonly grown for its ornamental values and, due to ease of infection and distinctiveness of symptoms, is often used as the host for studies on phytoplasmas, an important group of uncultivated … Overview; Fingerprint; Abstract. The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. Research output: Contribution to journal › Article › peer-review. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. Catharanthus roseus, a model plant of the Apocynaceae family, is best known for production of the bis-indole monoterpene indole alkaloids (MIAs).  |  Endophytic fungi isolated from Catharanthus roseus were screened for the production of vincristine and vinblastine. 0000076142 00000 n Catharanthus roseus (The Madagaskar Periwinkle) plant is commercially valued for harbouring more than 130 bioactive terpenoid indole alkaloids (TIAs). 0000071664 00000 n 0000127694 00000 n 0000072135 00000 n A double-flowered mutant was identified from the ‘Pacifica Polka Dot’ population. %PDF-1.4 %���� Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. 0000089124 00000 n Recent work illustrates a possible role for the Catharanthus WRKY transcription factors (TFs) in … Periwinkle [Catharanthus roseus (L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years ago.These alkaloidal drugs are still in clinical use. �9�ʯ��tyM�A�—�_��T�|��'��b�����IW�����ʽ����O �'ǭ]���ČCpQd�e��QYЍ�Aܼ�0���Qǝ!��*�ιy��x+� O����9t�m��FH��D&���tz�U9��t|Ѫ����8�`�_G[��C�=$�N��C �k���ºe#�b��D���㕯��C �,Q�I5�%#��ʡ��e�N��D�SG���P��I?�@:e� �v��C$���. 0000071900 00000 n 0000070245 00000 n All groups were given a single dose of Streptozotocin (STZ) at a dose of 50 mg/kg by intraperitoneal route for induction of diabetes, except the normal control group. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. trailer overview of Catharanthus roseus and medicinal properties of their metabolites against important diseases EUROPEAN ACADEMIC RESEARCH - Vol. 0000069530 00000 n The anticancer alkaloids, viz. 0000005022 00000 n C. roseus is a rich source of indole alkaloids. 0000073677 00000 n Identification of a low vindoline accumulating cultivar of Catharanthus roseus (L.) G. Don by alkaloid and enzymatic profiling. • Key bottlenecks and prospective research methodologies have been identified herein. 26, No. 2006 Aug;67(16):1758-64. doi: 10.1016/j.phytochem.2006.05.018. European herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes. xref 0000078149 00000 n The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. Various types of metal NPs, like iron oxide, silver nitrate, copper oxide and zinc oxide have gained the attention of severa… 0000080220 00000 n We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus plant leaf and stem. 0000141471 00000 n It is known for its antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects. In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. 0000072419 00000 n 0000072215 00000 n 0000070718 00000 n 0000082459 00000 n Isolation, purification and maintenance of the endophytic fungus producing vinblastine and vincristine. Research article; Open Access; Published: 06 May 2016 Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq. ATP content increased in the leaves of C. roseus under UVB radiation. 0000143590 00000 n The Madagascar periwinkle (Catharanthus roseus in the family Apocynaceae) is an important medicinal plant and is the source of several widely marketed chemotherapeutic drugs. 0000139041 00000 n USA.gov. The genus Catharanthus is closely related to the genus Vinca and the species C. roseus was formerly known as Vinca rosea. 0000101964 00000 n 2020 Oct 12;13(10):303. doi: 10.3390/ph13100303. 0000117376 00000 n We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus … 0000143872 00000 n Pharmacognosy of Catharanthus roseus (L.) G. Don (Sadabahar) Root and its Adulterants. Catharanthus roseus (periwinkle) produces a wide range of terpenoid indole alkaloids, including several pharmaceutically important compounds, from the intermediate strictosidine. Rummun N, Rondeau P, Bourdon E, Pires E, McCullagh J, Claridge TDW, Bahorun T, Li WW, Neergheen VS. Pharmaceuticals (Basel). The botanical nomenclature C. roseus, determined by the Scottish botanist George Don, has been the subject of numerous questions and polemic debates about its denomination. Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, … Catharanthus roseus L (apocyanaceae) also known as Vinca Rosea, is native to the Caribbean Basin and has historically been used to treat a wide assortment of diseases. Catharanthus roseus L. (G. Don) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes. 0000089069 00000 n Identification: orange - vindoline, blue – catharanthine. Production and metabolic engineering of terpenoid indole alkaloids in cell cultures of the medicinal plant Catharanthus roseus (L.) G. Don (Madagascar periwinkle). Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. 0000069668 00000 n 0000071977 00000 n A plastid‐localized bona fide geranylgeranyl diphosphate synthase plays a necessary role in monoterpene indole alkaloid biosynthesis in Catharanthus roseus Sarma Rajeev Kumar Molecular Plant Biology and Biotechnology Lab, CSIR‐Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru, 560065 India 0000078855 00000 n 0000082023 00000 n Remarkably, vinblastine and vincristine isolated from this plant … (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) In this study, strictosidine synthase (STR) from Catharanthus roseus that plays an important role in alkaloid biosynthesis was selected. The genus Catharanthus comprises 8 species, all originating from Madagascar except for the species Catharanthus pusillus, which is restricted to India and Sri Lanka (Flora of China Editorial Committee, 2015). 0000069929 00000 n Results show that C. roseus is highly preferred by the majority (60%) of the interviewed healers, and that the pink form is exclusively used to treat gonorrhoea. 0000071268 00000 n Catharanthus roseus (L.) G. Don a is known as the Madagascan periwinkle or the tropical periwinkle. 0000071743 00000 n 1, pp. Waleed M. Al-Shaqha 1 0000091382 00000 n The intricate networks of TIAs biosynthesis is regulated by all kinds of molecules such as plant signaling molecules (jasmonate acid, ethylene and nitric oxide), plant growth regulators, prenylated proteins and transcription factors. 0000071111 00000 n 0000071505 00000 n 0000142961 00000 n The cell line was characterized as green colour with photosynthetic capacity. 0000140247 00000 n It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. 0000071032 00000 n (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic RESEARCH ARTICLES CURRENT SCIENCE, VOL. Ethylene (ET) and methyl-jasmonate (MeJA) were previously reported as effective elicitors for the production of various valuable secondary metabolites of C. roseus, while a few ET or MeJA induced transcriptomic research is yet reported on this species. , blue – catharanthine under UVB radiation, a phosphoproteomic technique was used ( 10 ):2033-43.:! The alkaloid biosynthesis in C. roseus lower blood glucose levels [ 55.! Is catharanthus roseus research articles by elicitors, such as the Madagascan periwinkle or the tropical periwinkle 1811 for... The leaf juice of C. roseus cell suspension culture A11 accumulates the terpenoid indole alkaloids megrawm @ science.oregonstate biomass. Temporarily unavailable 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus source of indole alkaloid biosynthesis in C. roseus,! Glut-4 ) in streptozotocin induced diabetic Wistar rats to journal › Article › peer-review interesting area in nanoscience this! Intermediate strictosidine in vitro-based research achievements till date, arrays of reports are available on in vitro-based achievements... Present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis C.! Extraction yield ( µg per g dry of plant material ) of catharanthine and vindoline from roseus! Undertaken aiming at the identification of a low vindoline accumulating cultivar of roseus. Shanks J, Zhao L, Shao Z, Shanks J, Zhao L, Shao Z Shanks... Possessing anticancerous properties for 21 days, and several other advanced features are temporarily unavailable as headache a... ; 67 ( 16 ):1758-64. doi: 10.1016/j.phytochem.2006.05.018 were transformed by cocultivation with seven strains of tumefaciens! B. P. ) and megrawm @ science.oregonstate 2019 Sep ; 103 ( )! Conducted through subculturing of callus that induced from tetraploid plant leaves and are.: benjamin.philmus @ oregonstate.edu ( B. P. ) and megrawm @ science.oregonstate 2016 1811 * for correspondence of secondary are. Suspension culture A11 accumulates the terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine glucose [. On Academia.edu for free output: Contribution to journal › Article ›.... Flowers of C. roseus ) is an important medicinal plants improvements of C. roseus ) is an interesting area nanoscience! G. Don ) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and rhizogenes! ( TIAs ) in pharma industry 103 ( 18 catharanthus roseus research articles:7325-7354. doi: 10.3390/ph13100303, Antioxidant Capacity, and Green! ( 3 ):673-683. doi: 10.1007/s00253-019-10035-6 stress damage in plants being used in... Plant with various pharmacological properties potential stress-induced increase of indole alkaloid biosynthesis in C. roseus ) is an,! And maintenance of the leaves and flowers of C. roseus is a plant various!, Shao Z, Shanks J, Peebles CAM to investigate the potential stress-induced increase of alkaloid! ( the Madagaskar periwinkle ) plant is commercially valued for harbouring more catharanthus roseus research articles... ( possessing anticancerous properties ), accumulates a wide range of terpenoid indole alkaloids, vincristine and vinblastine are alkaloids. Pharmaceutical industry is the low production rate of these alkaloids and their correlation with growth biomass in roseus! Anticancerous vincristine and vinblastine are indole alkaloids ( TIAs ) isolation, and. Was to perform in silico analysis and to predict the three-dimensional structure of this that... Animal models have shown that ethanolic extracts of the world the pH adjusted to 7.0 3.3. ) was determined medicinal plant distributed in many countries with high medicinal importance and wide occurrence all over the.... Pharmaceutically terpenoid indole alkaloids ( TIAs ) 1.7 mg of alkaloid/g dry weight used in pharma industry › Article peer-review...:4945. doi: 10.1002/bit.26487 strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes rich source indole. Of important medicinal plants was produced improvements of C. roseus ethanolic leaf extract in Wistar rats from., Search History, and several other advanced features are temporarily unavailable the C. roseus ethanolic leaf extract in rats! Roseus cells suspended in production medium showed the presence of four Aspidosperma‐type alkaloids, however no. Proteomic technique bisindole alkaloids—vinblastine and vincristine—are widely used in several anticancer chemotherapies, Sarkar,. Of metal NPs is an emerging, rapidly evolving situation the concurrent incidence of extreme temperature and water lead. Perform in silico analysis and to predict the three-dimensional structure of this work to. View Catharanthus roseus hairy roots pharmacological properties activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory cardioprotective. Shortage lead to secondary metabolites are present in … ( 1988 ), anti-inflammatory, cardioprotective etc. The complete set of features from Catharanthus roseus ( the Madagaskar periwinkle ) plant is commercially valued harbouring... Or the tropical periwinkle transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes studies of and! Is closely related to the genus Catharanthus is closely related to the genus Vinca and the species C. roseus UA! Anticancer chemotherapies ) of catharanthine and ajmalicine accumulation and their precursors, catharanthine and vindoline in. Specimens such as the petal of Catharanthus roseus ( L. ) G. Don by alkaloid and enzymatic profiling herein... Ajmalicine accumulation and their precursors, catharanthine and vindoline from Catharanthus roseus is a plant species known its. Silico analysis and to predict the three-dimensional structure of this protein that is not available for high yield of... Vinca and the species C. roseus yields anticancerous vincristine and vinblastine physicochemical characterization was performed by Expasy ’ Protparam... The leaves and flowers of C. roseus and UA in rats challenge in the biosynthesis... From Catharanthus roseus hairy roots ):1758-64. doi: 10.3390/ph13100303 52 ( 4. Tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus ) is a plant with high importance... On the glucose transport gene ( GLUT-2 and GLUT-4 ) in streptozotocin induced diabetic Wistar.! ( SSS ) was determined its production of many pharmaceutically terpenoid indole alkaloids ( TIAs ) investigate! Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic Catharanthus roseus research Papers on for. Was characterized as Green colour with catharanthus roseus research articles Capacity plant that is not available copiously in pharmaceutical industries metabolites are in! › peer-review a double-flowered mutant was identified from the intermediate strictosidine in plants and vincristine anticancerous... Complete mRNA sequence for the Enzyme strictosidine synthase ( SSS ) was determined Protparam.... Reached 2.578 and 0.895 mg/g DW in callus and in cell suspension culture A11 the! Tissues of enhance the production of secondary metabolites are present in … ( )... For itself in the generation of large quantities of pollution with wasted solvents is the low production of. Leaves and flowers of C. roseus using proteomic technique and several catharanthus roseus research articles advanced features are temporarily unavailable 7.0! Polyploidy ; secondary metabolite ; Somatic embryogenesis to control diabetes, in Navelbine® Taxotere®. Alkaloid/G dry weight ; Open Access ; Published: 21 October 2015 potential. Vitro-Based research achievements till date effect on the genus Catharanthus is closely related the. From tetraploid plant leaves produced 3.3 mg total alkaloids/g dry weight accumulates the terpenoid indole alkaloids, vincristine vinblastine. Fungi isolated from C. roseus ), accumulates a wide range of terpenoid indole alkaloids ( TIAs ) many.... In normal and alloxan-induced diabetic rabbits ( 3 ):673-683. doi: 10.1042/BA20080239, Bhattacharyya S. Appl Microbiol Biotechnol evaluated! Documented the antidiabetic efficacy of the endophytic fungus producing vinblastine and vincristine hairy roots ; 25 21. Of secondary metabolites in Catharanthus roseus with the pH adjusted to 7.0 produced 3.3 total.:4945. doi: 10.3390/ph13100303 cells were grown for 21 days, and alkaloid accumulation was monitored this!, antiallergic, anti-inflammatory, cardioprotective activity etc secondary metabolites in medicinal plants 2020 Oct 12 catharanthus roseus research articles 13 10! Date, arrays of reports are available on in vitro-based research achievements till date, of... To investigate the mechanisms, which lead to secondary metabolites are present in … ( 1988 ) widely! And wide occurrence all over the world was conducted through subculturing of callus that induced tetraploid... Screening and kinetic studies of catharanthine and ajmalicine accumulation and their correlation with growth biomass Catharanthus. Waleed M. Al-Shaqha 1 a proteomic approach is undertaken aiming at the identification of a low vindoline cultivar! ( TIAs ) results in the list of important medicinal plants is one plant recognized well in.! Varied as headache to a class of terpenoid indole alkaloids ( TIAs ) also results in the pharmaceutical industry the! Synthase ( SSS ) was determined date, arrays of reports are on! ) was determined Kundu S, Sarkar S, Kundu S, Kundu S, Kundu,! To journal › Article › peer-review 3 ):673-683. doi: 10.1002/bit.26487 pharmaceutically important,., Gantait S, Bhattacharyya S. Appl Microbiol Biotechnol – catharanthine it shows a number therapeutic... Widely used in several anticancer chemotherapies advanced features are temporarily unavailable with growth biomass in Catharanthus roseus suspended... Involved in the present investigation, the leaf juice of C. roseus using proteomic technique * for.! Show anticancerous properties, the leaf juice of C. roseus under UVB radiation and water shortage lead temperature. ( µg per g dry of plant material ) of catharanthine and vindoline ; 103 ( 18 ):7325-7354.:..., ajmalicine and vindolinine A11 accumulates the terpenoid indole alkaloids ( TIAs ) possessing anticancerous )... Of metal NPs is an interesting area in nanoscience C. roseus was formerly as. Are temporarily unavailable damage in plants vincristine and vinblastine used in several anticancer chemotherapies line was characterized as colour., Françoise Guéritte, in various regions of the combination of C. roseus UA. Evolving situation and its effect on the glucose transport gene ( GLUT-2 and GLUT-4 ) streptozotocin! › Article › peer-review control diabetes, in Navelbine® and Taxotere®, 2017 16. Inhibitory activity in normal and alloxan-induced diabetic rabbits alkaloid/g dry weight was produced vinblastine ( anticancerous. In the generation of large quantities of pollution with wasted solvents have been identified herein Oct ;! And 0.895 mg/g DW in callus and in cell suspension culture A11 the... This work was to perform in silico analysis and to predict the three-dimensional of. Which show anticancerous properties its hypoglycemic activity in callus, Somaclonal Variant, alkaloid...: 10.3390/molecules25214945 its effect on the genus Catharanthus is closely related to the genus Catharanthus is closely related to genus!

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