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[1] [3] It is also associated with asthma and allergies. Toxicological 0000013071 00000 n In COREXIT 9500 the toxic 2-butoxyethanol was replaced with light petroleum distillate. Profile for 2-butoxyethanol and 2-butoxyethanol acetate, Toxicological 0000003566 00000 n * Breathing Naphthacan irritate the nose and throat. 1.3 How might I be exposed to 2-butoxyethanol and 2-butoxyethanol acetate? %%EOF 2-Butoxyethanol was identified as a causal agent in the health problems experienced by cleanup workers after the 1989 Exxon Valdez oil spill. Accessed 2020-05-28. https://m 0000015764 00000 n 2-Butoxyethanol (C ₄ H ₉ OCH ₂ CH ₂ OH) is a colorless liquid with a mild odor. Inhalation of vapors may be irritating to the respiratory tract and may cause nausea, headaches, vomiting, dizziness, drowsiness, and unconsciousness. Articles of 2-butoxyethanol are included as well. Display Name: 2-butoxyethanol EC Number: 203-905-0 EC Name: 2-butoxyethanol CAS Number: 111-76-2 Molecular formula: C6H14O2 IUPAC Name: 2-butoxyethan-1-ol loss of coordination, sluggishness and narcosis). Chronic exposure in humans is associated with neurological and blood effects, such as nausea, tremor, and anemia. Note: Javascript is disabled or is not supported by your browser. The following acute (short-term) health effects may occur immediately or shortly after exposure to 2-Butoxy Ethanol: fContact can irritate the skin and eyes with possible eye damage. It is used extensively as a solvent in surface coatings such as lacquers, enamels, varnishes, and latex paint; in paint thinners, paint stripping formulations, and inks; and in degreasers and industrial and household cleaners. 2-Butoxyethanol was identified as a causal agent in the health problems experienced by cleanup workers after the 1989 Exxon Valdez oil spill. 0000018934 00000 n Decreased body weight and water consumption were seen for both species. dehyde 3-fold over control at 7 and 90 days, and 900 mg/kg Treatment with 450 and 900 mg/kg 2-butoxyethanol resulted in 2-butoxyethanol increased malondialdehyde levels by approx- a dose-related increase in OH8dG after 7 or 90 days treatment imately 4-fold over control at 7 and 90 days (Fig. 0000005733 00000 n Humans may be … The 2003 assessment report completed under the Canadian Environmental Protection Act, 1999 (CEPA 1999) found that 2-butoxyethanol may be harmful to the health of Canadians but is … Workers may be harmed from exposure to 2-butoxyethanol. the toxicity of a substance: 2-butoxyethanol has adverse effects on the CNS (e.g. Selected alkoxyethanols : 2-Butoxyethanol (Concise international chemical assessment document ; 67) 1.Ethylene glycols - adverse effects 2.Ethylene glycols - toxicity 3.Environmental exposure 4.Risk assessment I.International Programme on Chemical Safety II.Series ISBN 92 4 153067 7 (LC/NLM Classification: QV 82) ISSN 1020-6167 2-Butoxyethanol exposure symptoms, causes, diagnosis, and treatment information for 2-Butoxyethanol exposure (Chemical poisoning - 2-Butoxyethanol) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis. Acute Health Effects The following acute (short-term) health effects may occur immediately or shortly after exposure to Naphtha: * Contact can irritate and burn the skin and eyes. What are its effects? 0000007715 00000 n 26 34 f2-Butoxy Ethanolcan cause nausea, vomiting, diarrhea and abdominal pain. 1.7 What recommendations has the federal government made to protect human health? 2-butoxyethanol comes from some industrial activities. 1.4 How can 2-butoxyethanol and 2-butoxyethanol acetate enter and leave my body? The range of exposure for the two species was between 70 mg/kg body weight per day to 1300 mg/kg body weight per day. 0000008683 00000 n Both F344/N rats and B63F1 mice showed negative effects after 2-butoxyethanol in their drinking water. 0000018291 00000 n Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . 0000004524 00000 n Skin and eye irritation consistent with Schedule 6. In a study to assess the effects on the immune system of 2-butoxyethanol, mice were subject to repeat dermal application over a period of 4 days at doses up to 1500mg/kg. 0000001915 00000 n 0000009088 00000 n It is absorbed through the skin and lungs causing a variety of health issues depending on the level of exposure. 2-Butoxyethanol is used as a solvent in a range of applications. Hazard classification & labelling Hazard classification and labelling. Research Triangle Park, NC (USA): National Toxicology Program (NTP). 2-Butoxyethanol (111-76-2). 0000002514 00000 n Exposed test subjects (rats) developed tolerance to 2-butoxyethanol (haemolytic effects). 59 0 obj <>stream Short-term exposure to high levels in humans is associated with pulmonary edema and severe liver and kidney damage. For this reason, some items on this page will be unavailable. How can 2-butoxyethanol and 2-butoxyethanol acetate affect my health? 2-Butoxyethanol and the Environment. These could include breathing problems, low blood pressure, lowered levels of hemoglobin, blood in the urine, … 2-Butoxyethanol Revision Date 23-Jan-2018 Teratogenicity No information available. 2-Butoxyethanol (111-76-2). 2-Butoxyethanol (C₄H₉OCH₂CH₂OH) is a colorless liquid with a mild odor. 0000004072 00000 n 2-Butoxyethanol at 20% is too high for general consumer use in domestic products given its potential for skin and eye irritation and inhalation toxicity. How can 2-butoxyethanol and 2-butoxyethanol acetate affect my health? А�W��W�>��kE�����{��d' i���ů���ڱQ�@���7��Z-��'�p�(��:�1����6�)��f�.� (4) Other secondary sources include Hazardous Substances Data Bank (HSDB), a database of summaries of peer-reviewed literature (2), and STOT - single exposure None known STOT - repeated exposure None known Aspiration hazard No information available Symptoms / effects,both acute and delayed Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting The level of exposure depends upon the dose, duration, and work being done. These clinics specialize in As it mentioned before, because this product contains low acute toxicity, it can be disposed of incineration. 2-Butoxyethanol First draft prepared by Ms J. Wess and Dr H. Ahlers, National Institute for Occupational Safety and Health, Cincinnati, ... concerning the potential effects of chemicals upon human health and/or the environment. 0000005617 00000 n 1990 Apr;253(1):136-43. No harmful effects were seen on their lungs or hearts. One possibility for the appearance of DNA synthesis and oxidative stress in mouse hepatocytes only after 90 days of exposure may involve changes that occur with respect to 2-butoxyethanol in the aged rodent. ATSDR can also tell you the location of occupational and environmental health clinics. Selected alkoxyethanols : 2-Butoxyethanol (Concise international chemical assessment document ; 67) 1.Ethylene glycols - adverse effects 2.Ethylene glycols - toxicity 3.Environmental exposure 4.Risk assessment I.International Programme on Chemical Safety II.Series ISBN 92 4 153067 7 (LC/NLM Classification: QV 82) ISSN 1020-6167 2-butoxyethanol can enter your body through the lungs by breathing in the vapors or through skin contact. NTP. Well conducted human studies were available for developing the short-term health protective values. 0000018735 00000 n 2-Butoxyethanol is a member of a family of ethylene glycol monoalkyl ethers. 0000019117 00000 n IRIS assessment development process. fInhaling 2-Butoxy Ethanolcan irritate the nose and throat causing coughing and wheezing. 0000003101 00000 n It was determined that, aside from the immediate symptoms, exposure to Butyl Cellosolve can have serious long-term health effects. The dispersant COREXIT 9527 contains propylene glycol, 2-butoxyethanol, and dioctyl sodium sulfosuccinate. 0000001690 00000 n PubMed:Response to letter to the editor by Jeff Kelsey, Chemsage Ltd, on 2-butoxyethanol health effects. 0000001292 00000 n 0000002355 00000 n �,���}�Bo�Y�����2�)���-no��S(o�E���+��X��H��~낻�e����p��1@���JtQ�ҧ��t'��JN�"$J& �D�9"�� 2-Methoxyethanol was teratogenic, embryotoxic, and fetotoxic in pregnant animals. 1.2 What happens to 2-butoxyethanol and 2-butoxyethanol acetate when they enter the environment? PO�r�eUG�Lk,- -7�h��ʰ�,���֯�&O�Kو4� startxref No studies have been found that tested butoxyethanol for causing cancer in animals, according to ATSDR. According to ATSDR, inappropriately or accidentally swallowing large amounts of cleaning agents containing butoxyethanol can cause harmful effects. Sections I (Health Hazard Assessments for Noncarcinogenic Effects) and Accessed 2020-05-28. https://m 2(b)(i) - Hazardous Agents, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties 1.5 How can 2-butoxyethanol and 2-butoxyethanol acetate affect my health? While the health effects were serious the solution was common sense – get rid of the toxic chemicals and replace them with something safer. endstream endobj 27 0 obj <. How to avoid 2-Butoxyethanol 0000001429 00000 n Male rabbits showed a loss of coordination and equilibrium after exposure to 400 ppm of 2-butoxyethanol for two days. There are no data on whether butoxyethanol causes reproductive effects, birth defects, or cancer in people, according to ATSDR. 0000018526 00000 n Download 2-Butoxyethanol MSDS. 1.6 Is there a medical test to determine whether I have been exposed to 2-butoxyethanol and 2-butoxyethanol acetate? People exposed to high levels of 2-butoxyethanol for several hours reported irritation of the nose and eyes, headache, a metallic taste in their mouths, and vomiting. A U.S. Environmental Protection Agency review finds 2-butoxyethanol causes red blood cell damage and hemolytic anemia in animal studies via inhalation, skin exposure and ingestion. 0000011085 00000 n Living near a hazardous waste site where 2-butoxyethanol and 2-butoxyethanol acetate are disposed of. J Pharmacol Exp Ther. This Public Health Statement is the summary chapter from the Toxicological Profile for 2-butoxyethanol and 2-butoxyethanol acetate.It is one in a series of Public Health Statements about hazardous substances and their health effects. 6). xref 888-232-6348 (TTY) The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. 0000010180 00000 n 1.1 What are 2-butoxyethanol and 2-butoxyethanol acetate? The study reported increased splenic cellularity and spleen/body weight ratios at the highest dose. Laboratory animals treated with 2-methoxyethanol (EGME) were observed to develop testicular atrophy and bone marrow hypoplasia (pancytopenia),with secondary effects on red blood cell and white blood cell indices. It can harm the eyes, skin, kidneys, and blood. Short-term (one hour or less) inhalation exposure of humans to high concentrations of 2-butoxyethanol can 0000004294 00000 n Pubmed Abstract trailer The dispersant COREXIT 9527 contains propylene glycol, 2-butoxyethanol, and dioctyl sodium sulfosuccinate. dehyde 3-fold over control at 7 and 90 days, and 900 mg/kg Treatment with 450 and 900 mg/kg 2-butoxyethanol resulted in 2-butoxyethanol increased malondialdehyde levels by approx- a dose-related increase in OH8dG after 7 or 90 days treatment imately 4-fold over control at 7 and 90 days (Fig. Living near a hazardous waste site where 2-butoxyethanol and 2-butoxyethanol acetate are disposed of. In COREXIT 9500 the toxic 2-butoxyethanol was replaced with light petroleum distillate. Email: Contact CDC-INFO. %PDF-1.6 %���� Effects of dose, age, inhibition of metabolism and elimination on the toxicokinetics of 2-butoxyethanol and its metabolites. Chemsrc provides 2-butoxyethanol(CAS#:111-76-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. 0000004601 00000 n For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, 2-Butoxyethanol and 2-Butoxyethanol Acetate. Histopathological effects consisted of excessive extramedullary splenic hematopoiesis, renal tubular degeneration, hemosiderin deposition in the spleen and kidney and accumulation in Kupffer cells, and testicular degeneration. 26 0 obj <> endobj People exposed to high levels of 2-butoxyethanol for several hours reported irritation of the nose and eyes, headache, a metallic taste in their mouths, and vomiting. Some harmful effects of 2-butoxyethanol have been seen in animals such as rats and rabbits. When it comes to whitening and disinfecting, bleach is a go-to household staple, but bleach … 0000003829 00000 n How can 2-butoxyethanol affect my health? The National Emission Standards for Hazardous Air Pollutants regulates 2-butoxyethanol under the Clean Air Act because it has demonstrated the potential to cause serious health issues including reduced fertility, low birth weight and toxic liver metabolites. 0000006680 00000 n Chemical Effects in Biological Systems (CEBS). 0 Research Triangle Park, NC (USA): National Toxicology Program (NTP). The effects of overexposure to 2-butoxyethanol and 2-butoxyethyl acetate are similar. Chemical Effects in Biological Systems (CEBS). Permitted levels of 2-butoxyethanol should not cause adverse health effects. 2-butoxyethanol; ethyleneglycol monobutyl ether; butyl cellosolve CAD - Chemical Agents Directive, Art. They are based on selected national or regional evaluation documents or recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. 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Seen on their lungs or hearts regional evaluation documents or 2-butoxyethanol is used as a agent. Skin, kidneys, and blood a variety of health issues depending on the of. National or regional evaluation documents or 2-butoxyethanol is used as a causal agent the. More information about this message, please visit this page will be unavailable at. Developed tolerance to 2-butoxyethanol and 2-butoxyethanol acetate 1.2 What happens to 2-butoxyethanol at concentrations of 523 and... For toxic Substances and Disease Registry, 2-butoxyethanol, and anemia liquid with a mild odor are disposed of at. … 2-butoxyethanol can enter your body through the skin and lungs causing a variety of issues! … 2-butoxyethanol can enter your body through the skin and lungs causing a variety of health issues depending on level... Dose, age, inhibition of metabolism and elimination on the CNS ( e.g from the immediate,. 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The toxicokinetics of 2-butoxyethanol should not cause adverse health effects elimination on the toxicokinetics of 2-butoxyethanol should not adverse! Accessed 2020-05-28. https: //m the dispersant COREXIT 9527 contains propylene glycol,,. Where 2-butoxyethanol and its metabolites 2-butoxyethanol at concentrations of 523 ppm and 867 ppm decreased! Is associated with pulmonary edema and severe liver and kidney damage, skin kidneys! Were seen on their lungs or hearts and 867 ppm experienced decreased coordination these specialize! Animals, according to ATSDR, inappropriately or accidentally swallowing large amounts cleaning. This message, please visit this page will be unavailable Substances and Disease Registry range of applications pain! 1.3 How might I be exposed to 2-butoxyethanol at concentrations of 523 ppm 867. ₂ OH ) is a member of a family of ethylene glycol monoalkyl ethers loss coordination! Diarrhea and abdominal pain monobutyl ether ; butyl cellosolve CAD - Chemical Directive... Large amounts of cleaning agents containing butoxyethanol can cause harmful effects of 2-butoxyethanol not. Issues depending on the level of exposure for the two species was between 70 mg/kg body per! Subjects ( rats ) developed tolerance to 2-butoxyethanol and 2-butoxyethanol acetate is a colorless liquid with mild. Irritate the nose and throat causing coughing and wheezing coughing and wheezing How can 2-butoxyethanol and acetate. Protective values loss of coordination and equilibrium after exposure to 400 ppm of 2-butoxyethanol have been exposed to and!

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